The Efficacy of Insulin Detemir Versus Neutral Protamine Hagedorn Insulin in Treatment of Gestational Diabetes Mellitus During Pregnancy

Abstract

Background: The gestational diabetes mellitus (GDM) is one of the most common medical conditions during pregnancy. Insulin is considered to be safe in pregnancy. As compared to Neutral Protamine Hagedorn Insulin (NPH)” insulin detemir shows good safety and efficacy for future use in GDM for better cure.

Objectives: To compare the outcome of insulin detemir plus Novolin R versus NPH plus Novolin R in women with GDM.

Methods: This experimental study was conducted in outpatient Department of Obstetrics & Gynae., Unit I, Services Hospital, Lahore from February 2021 to February 2022. After taking ethical approval and informed consent, patients were selected by probability double blind sampling technique and randomized in two groups. In group A, patient received insulin detemir plus Novolin R. In group B, patients received insulin NPH plus Novolin R. At baseline and after 3 weeks of treatment, fasting and post-prandial sugar levels were measured and compared for mean change in blood sugar level.

Results: In detemir group, the mean fasting blood sugar level was 156.74±16.80 g/dl, which was reduced to 99.34±16.82 g/dl after treatment. In NPH group, the mean fasting blood sugar level was 155.01±18.81 g/dl, and reduced to 104.70±18.97 g/dl after treatment with significant (p <0.05). In detemir group, the mean post-prandial sugar level was 222.44±37.88 g/dl, and reduced to 142.00±15.74 g/dl after treatment. In NPH group, the mean post-prandial sugar level was 210.90±38.39 g/dl, and reduced to 147.97±7.05 g/dl after treatment and the reduction was significant (p-value <0.05).

Conclusion: The detemir was found to ....................