Estimation of Cardiac Troponin I and T in Patients with Clinically Stable Chronic Kidney Disease

Abstract

Background: Patients with chronic kidney disease (CKD) have an increased prevalence of cardiovascular disease with declining renal function. However, the concentration of cardiac troponins is increased among CKD patients in the absence of clinical evidence of acute myocardial infarction. In this study cardiac troponin I and cardiac troponin T concentrations were studied in patients with CKD.

Objective: To determine cardiac troponin I and T levels in patients with clinically stable chronic kidney disease presenting to a tertiary care hospital in Rahim Yar Khan.

Methods: This cross-sectional study was conducted in the Department of Chemical Pathology, Sheikh Zayed Hospital, Rahim Yar Khan from January to September 2024. A total of 222 individuals with CKD without any known cardiac diseases were included. Serum cTnI and cTnT were measured on chemiluminescence immunoassay analyzer. Mann-Whitney U test and Kruskal-Wallis H test followed by post-hoc analysis were used for the analysis of significance. Spearman rank was used to evaluate correlation of eGFR with cTnT and cTnI.

Results A total of 222 patients, 142 males (64%) and 80 females (36%), with CKD were included. There was a statistically significant difference between stages of CKD and cTnT levels, p value <0.001 but not between stages of CKD and cTnI levels, p value =0.114. The eGFR showed a negative correlation to cTnT (r = -0.456) but had a negligible negative correlation (r =-0.140) with cTnI.

Conclusion: The level of cTnT increases across CKD stages however the concentration of cTnI appears to be stable.